Chiral 1,4-benzodiazepines. XII. Conformation in a solution of 7-chloro-5-phenyl-3(S)methyl-1,3-dihydro-2H-1,4-benzodiazepine |
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Authors: | E Decorte R Toso T Fajdiga G Comisso F Moimas A Sega V Sunji A Lisini |
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Institution: | E. Decorte,R. Toso,T. Fajdiga,G. Comisso,F. Moimas,A. Sega,V. Sunji?,A. Lisini |
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Abstract: | Deuterium labeled congeners of 7-chloro-5-phenyl-3(S)-methyl-1,3-dihydro-2H-1,4-benzodiazepine ( 8 ), i.e., compounds 9 and 16-18 were prepared and their lis-nmr spectra run. For computational studies compounds 9 and 16 were chosen. The results of lis measurements revealed that 16 is present in more than 97% in the boat-like conformation I (Scheme 3). |
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