Réactions entre l'indole et les chlorures d'acides,en milieu basique: Synthèse d'amides de l'ortho [bis(indolyl-3)]-2 éthyl,aniline

Acid chlorides react with indole in alkaline aqueous medium and yield amides of o-2-(3,3'-bisindoly)ethyl]aniline which is in fact a trimer of indole. Their formation can be understood as follows: autocondensation of indole to give the 2,3-diindole; acylation of this compound on the nitrogen atom of the saturated pentacycle; attachement of a new indole molecule on the l-acyldiindole with cleavage of the ring carrying the amide function.