Large-scale synthesis of all stereoisomers of a 2,3-unsaturated C-glycoside scaffold |
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| Authors: | Gerard Baudouin Marié Jean-Charles Pandya Bhaumik A Lee Maurice D Liu Haibo Marcaurelle Lisa A |
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| Affiliation: | Chemical Biology Platform, The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA. |
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| Abstract: | All stereoisomers of a highly functionalized 2,3-unsaturated C-glycoside can be accessed in 10-100 g quantities from readily available starting materials and reagents in 3-7 steps. These chiral scaffolds contain three stereogenic centers along with orthogonally protected functional groups for downstream reactivity. |
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