三种环氧孕甾衍生物的合成和光谱特性研究

合成了三种环氧孕甾衍生物：6-亚甲基-16α,17α-环氧孕甾-4-烯-3,20-二酮，6-甲基-16α,17α-环氧孕甾-4，6-二烯-3,20-二酮和6-甲基-16α,17α-环氧孕甾-4-烯-3,20-二酮。其中6-甲基-16α,17α-环氧孕甾-4，6-二烯-3,20-二酮未见文献报道。同时应用红光谱(FTIR)、紫外光谱(UV)、及核磁共振氢谱(1H NMR)对三种甾体化合物的结构进行了研究。结果表明，三种甾体化合物结构上的差异在FTIR，UV，1H NMR谱中有明显的特征并表现出一定的规律。

Synthesis and Spectral Analysis of Three Kinds of Epoxy Pregnene Derivatives

Three kinds of derivatives, 16alpha, 17alpha-epoxy-6-methylene-pregn-4-ene-3,20-dione(EMPD I), 16alpha, 17alpha-epoxy-6-methyl-pregn-4,6-diene-3,20-dione (EMPD II) and 16alpha, 17alpha-epoxy-6-methyl-pregn-4-ene-3, 20-dione(EMPD III) were synthesized and their FTIR, UV and 1H NMR spectra were described. EMPD II is a novel compound. In the UV spectra, the maximum absorptions peaks of EMPD I, EMPD II and EMPD III are at 259, 287 and 239 nm respectively. Their IR spectra are also obviously different. For EMPD I, there are two absorption peaks, which are respectively at 3084 cm(-1) originated from ==CH2 and 3 030 cm(-1) from C==CH--. For EMPD II and III, there is only one absorption peak at 3054 cm(-1). From 1710-1660 cm(-1), only one absorption peak appears for EMPD III, but two appear for EMPD I and EMPD II. In 1H NMR spectrum, the peaks at 4.92 (s, 1H), 5.06 (s, 1H) and 5.88 (s, 1H) were observed for EMPD I; the peaks at 1.83 (s, 3H), 5.87 (s, 1H) and 5.85 (s, 1H) for EMPD II; while the peaks at 1.06-1.07 (d, 3H), 5.78 ppm (s, 1H, 1 ppm=l nicrog x mL(-1)), for EMPD III.