| Solid-phase Synthesis of PNA Monomer by Ugi Four-component Condensation Reaction |
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| 作者姓名： | WenHaoWANG XiaoMinZOU XinZHANG YiQiuFU PingXU |
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| 作者单位： | DepartmentofMedicinalChemistry,SchoolofPharmaceuticalSciences,PekingUniversity,Beijing100083 |
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| 摘 要： | Peptide nucleic acids (PNA) oligomers were synthesized in most cases by peptide a peptide synthesis from N-protected monomers. In this work a new method of obtaining PNA monomer by Ugi four-component condensation reaction was tested by solid-phase synthesis. The Fmoc protected PNA monomer was build up with thymin-l-yl acetic acid, 3-methylbutyl aldehyde, Fmoc protected aminoethyl isocyanide and Gly-Wang resin.
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| 关 键 词： | 固相合成方法 PNA 缩氨酸核酸 浓缩反应 异氰化物 |
Solid-phase Synthesis of PNA Monomer by Ugi Four-component Condensation Reaction |
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| WenHaoWANG XiaoMinZOU XinZHANG YiQiuFU PingXU.Solid-phase Synthesis of PNA Monomer by Ugi Four-component Condensation Reaction[J].Chinese Chemical Letters,2005,16(5):585-588. |
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| Authors: | Wen Hao WANG Xiao Min ZOU Xin ZHANG Yi Qiu FU Ping XU |
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| Institution: | Wen Hao WANG,Xiao Min ZOU,Xin ZHANG,Yi Qiu FU,Ping XU Department of Medicinal Chemistry,School of Pharmaceutical Sciences,Peking University,Beijing 100083 |
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| Abstract: | Peptide nucleic acids (PNA) oligomers were synthesized in most cases by peptide synthesis from N-protected monomers. In this work a new method of obtaining PNA monomer by Ugi four-component condensation reaction was tested by solid-phase synthesis. The Fmoc protected PNA monomer was build up with thymin-1-yl acetic acid, 3-methylbutyl aldehyde, Fmoc protected aminoethyl isocyanide and Gly-Wang resin. |
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| Keywords: | Peptide nucleic acids (PNA) Ugi four-component condensation reaction (U-4CR) Solid-phase synthesis Isocyanide |
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