GLUCOSE ADMINISTRATION AUGMENTS IN VIVO UPTAKE AND PHOTOTOXICITY OF THE TUMOR-LOCALIZING FRACTION OF HEMATOPORPHYRIN DERIVATIVE |
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| Authors: | James P Thomas Albert W Girotti |
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| Institution: | Department of Biochemistry, Medical College of Wisconsin Milwaukee, WI 53226, USA |
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| Abstract: | Rhabdomyosarcoma tumors in rats made hyperglycemic by multiple injections of glucose exhibited a transient decrease in pH and an increased ability to accumulate derivatives of hematoporphyrin (HPD). Photoradiation of tumors in glucose/HPD-treated animals produced a greater cell kill than in galactose/HPD-treated controls. A therapeutic benefit of glucose administration in conjunction with HPD-phototherapy is suggested. |
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