Nature-inspired total synthesis of (-)-fusarisetin A |
| |
Authors: | Xu Jing Caro-Diaz Eduardo J E Trzoss Lynnie Theodorakis Emmanuel A |
| |
Institution: | Department of Chemistry and Biochemistry, University of California-San Diego , 9500 Gilman Drive, La Jolla, California 92093-0358, United States. |
| |
Abstract: | A concise, protecting group-free total synthesis of (-)-fusarisetin A (1) was efficiently achieved in nine steps from commercially available (S)-(-)-citronellal. The synthetic approach was inspired by our proposed biosynthesis of 1. Key transformations of our strategy include a facile construction of the decalin moiety that is produced via a stereoselective IMDA reaction and a one-pot TEMPO-induced radical cyclization/aminolysis that forms the C ring of 1. Our route is amenable to analogue synthesis for biological evaluation. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|