Organocatalytic asymmetric 1,4-addition of aldehydes to acridiniums catalyzed by a diarylprolinol silyl ether |
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Authors: | Liang Tao Xiao Jian Xiong Zhiyi Li Xingwei |
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Affiliation: | Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian, 116023, PR China. |
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Abstract: | The organocatalytic enantioselective 1,4-addition of aldehydes to acridiniums catalyzed by diarylprolinol silyl ether was achieved to furnish chiral acridanes in both high yields (82-96%) and excellent enantioselectivities (up to 99% ee), which also provides the highly enantioselective intermolecular α-alkylation of aldehydes with acridiniums salt. |
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