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Di-n-butyltin and diethyltin monofluorobenzoates: Synthesis,spectroscopic characterization and in vitro antitumor activity |
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| Authors: | Marcel Gielen Abdelaziz El Khloufi Monique Biesemans Rudolph Willem |
| Abstract: | The di-n-butyltin(IV) and diethyltin(IV) fluorobenzoates [FC6H4COO]2SnR2 and (FC6H4COOR2Sn)2O have been synthesized and characterized spectroscopically. Their in vitro antitumor activity against two human tumor cell lines, MCF-7, a mammary tumor, and WiDr, a colon carcinoma, as well as against the NCI cell panel, is satisfactory. |
| Keywords: | Organotin synthesis Mö ssbauer 1H NMR 13C NMR antitumor activity |