| Total Synthesis of Phakellistatin 13 by Solution Method |
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| 作者姓名： | Qing Feng JIANG You Jun ZHOU Jian Zhong YAO Jia Guo LU Ju ZHU Chun Quan SHENG Can Hui ZHENG Bing YAO |
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| 作者单位： | Qing Feng JIANG，You Jun ZHOU，Jian Zhong YAO，Jia Guo LU，Ju ZHU，Chun Quan SHENG，Can Hui ZHENG，Bing YAO Department of Medicinal Chemistry，School of Pharmacy，Second Military Medical University，Shanghai 200433 |
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| 摘 要： | Since George R. Pettit’s group isolated cycloheptapeptide phakellistatin 1 from sponge1, over ten similar cyclic peptides have been obtained2-5. Phakellistatin 134 (Figure 1) is a cycloheptapeptide isolated from the brown snubby sponge from the South Chi…
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| 关 键 词： | 海洋环肽类化合物 抗癌化合物 液相合成 环缩氨酸 总合成 |
| 收稿时间： | 2006-03-03 |
Total Synthesis of Phakellistatin 13 by Solution Method |
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| Qing Feng JIANG You Jun ZHOU Jian Zhong YAO Jia Guo LU Ju ZHU Chun Quan SHENG Can Hui ZHENG Bing YAO.Total Synthesis of Phakellistatin 13 by Solution Method[J].Chinese Chemical Letters,2006,17(8):995-998. |
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| Authors: | Qing Feng JIANG You Jun ZHOU Jian Zhong YAO Jia Guo LU Ju ZHU Chun Quan SHENG Can Hui ZHENG Bing YAO |
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| Abstract: | Phakellistatin 13 is a good antitumor lead compound isolated from halobios. It was synthesized first time by solution method in combination of stepwise coupling and segment condensation. Final deprotection and cyclization were achieved according to our designed method, which was different from the reported process. The spectral data of synthetic product is consisted with literatureal data of natural product. Total synthesis of phakellistatin 13 is a significant achievement to further study of its derivatives and developing novel antitumor drugs. |
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| Keywords: | Phakellistatin 13 solution-phase synthesis cyclopeptide |
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