An acid-catalyzed macrolactonization protocol |
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| Authors: | Trost Barry M Chisholm John D |
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| Institution: | Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. |
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| Abstract: | reaction: see text] An efficient macrolactonization protocol devoid of any base was developed derived from the use of vinyl esters in transesterification. Subjecting a hydroxy acid and ethoxyacetylene to 2 mol % RuCl(2)(p-cymene)](2) in toluene followed by addition of camphorsulfonic acid or inverse addition provided macrolactones in good yields. |
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