Synthesis of cis-solamin using a permanganate-mediated oxidative cyclization |
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| Authors: | Cecil Alexander R L Brown Richard C D |
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| Affiliation: | Department of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK. |
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| Abstract: | [reaction: see text] cis-Solamin (1) and its diastereoisomer 14 have been synthesized in 13 steps using the diastereoselective permanganate-promoted oxidative cyclization of 1,5-dienes to create the tetrahydrofuran diol core. Notably, no protecting groups are required during the stages of fragment assembly. |
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