| 恶性胸膜间皮瘤中间皮素表达的临床病理相关性及其预后意义 |
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| 引用本文： | 李彬,李素芬,王唯斯,杨娜,自加吉,熊伟.恶性胸膜间皮瘤中间皮素表达的临床病理相关性及其预后意义[J].井冈山大学学报（自然科学版）,2021,42(2):50-55. |
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| 作者姓名： | 李彬 李素芬 王唯斯 杨娜 自加吉 熊伟 |
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| 作者单位： | 大理大学基础医学院生物化学与分子生物学教研室,云南,大理 671000;大理大学基础医学院病理学教研室,云南,大理 671000;大理大学基础医学院生物化学与分子生物学教研室,云南,大理 671000;云南省高校临床生物化学检验重点实验室,云南,大理 671000 |
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| 基金项目： | 国家自然科学基金项目（31601155） |
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| 摘 要： | 通过探讨间皮素(MSLN)与恶性胸膜间皮瘤临床病理之间的相关性及其预后意义。采用R 3.6.3对美国公共癌症基因数据库(TCGA)进行数据挖掘和分析,利用Oncomine数据库对非癌组织与癌组织中MSLN的表达量进行比较分析,采用基因表达谱动态分析(GEPIA)构建Kaplan-Meier生存模型探究MSLN表达量对恶性胸膜间皮瘤患者预后的影响,使用c Bioportal进行MSLN基因相关性可视化分析。结果表明,MSLN在正常组织中低表达,恶性胸膜间皮瘤组织中高表达;MSLN的表达水平与恶性胸膜间皮瘤的肿瘤类型及组织学诊断类型相关;在MPM患者中,MSLN高表达的患者总生存率显著高于MSLN低表达的患者。因此,间皮素有望作为恶性胸膜间皮瘤诊断或治疗的潜在新靶点。
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| 关 键 词： | 恶性胸膜间皮瘤 间皮素 数据挖掘 预后意义 |
| 收稿时间： | 2020/12/16 0:00:00 |
| 修稿时间： | 2021/1/18 0:00:00 |
CLINICOPATHOLOGIC CORRELATION OF MESOTHELIN EXPRESSION IN MALIGNANT PLEURAL MESOTHELIOMA AND ITS PROGNOSTIC SIGNIFICANCE |
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| LI Bin,LI Su-fen,WANG Wei-si,YANG N,ZI Jia-ji and XIONG Wei.CLINICOPATHOLOGIC CORRELATION OF MESOTHELIN EXPRESSION IN MALIGNANT PLEURAL MESOTHELIOMA AND ITS PROGNOSTIC SIGNIFICANCE[J].Journal of Jinggangshan University(Natural Sciences Edition),2021,42(2):50-55. |
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| Authors: | LI Bin LI Su-fen WANG Wei-si YANG N ZI Jia-ji and XIONG Wei |
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| Institution: | Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Dali University, Dali, Yunnan 671000, China,Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Dali University, Dali, Yunnan 671000, China,Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Dali University, Dali, Yunnan 671000, China,Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Dali University, Dali, Yunnan 671000, China,Department of Pathology, College of Basic medical Sciences, Dali University, Dali, Yunnan 671000, China and Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Dali University, Dali, Yunnan 671000, China;Laboratory of Clinical Biochemistry Test of Yunnan Province, Dali University, Dali, Yunnan 671000, China |
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| Abstract: | This study will further discuss the relationship between MSLN and malignant pleural mesothelioma. In the present study, R 3.6.3 was used for data mining and analysis of the US public cancer gene database (TCGA), and the Oncomine database was used to compare and analyze the expression of MSLN in non-cancer and cancer tissues, and dynamic analysis of gene expression profiling (GEPIA) was used to build a Kaplan-Meier survival model for exploring the effect of MSLN expression on the prognosis of patients with malignant pleural mesothelioma, and the cBioportal was used for visual analysis of MSLN gene correlation. The expression of MSLN was low in normal tissues, but high in cancer tissues; the expression of MSLN was correlated with the tumor type of malignant pleural mesothelioma; among MPM patients, the overall survival rate of patients with high MSLN expression was significantly higher than that with low MSLN expression. In conclusion, mesothelin can be used as a new target for the diagnosis or treatment of malignant pleural mesothelioma, which lays a theoretical foundation for the future attack of related cancers. |
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| Keywords: | malignant pleural mesothelioma mesothelin data mining prognosis |
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