| 表层纳米氧化锆包覆硅球色谱载体的制备和表征 |
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| 引用本文： | 敦惠娟,宋秀芹,魏雨,李永民,陈立仁. 表层纳米氧化锆包覆硅球色谱载体的制备和表征[J]. 高等学校化学学报, 2003, 24(12): 2192-2194 |
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| 作者姓名： | 敦惠娟 宋秀芹 魏雨 李永民 陈立仁 |
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| 作者单位： | 1. 中国科学院兰州化学物理研究所, 兰州 730000;2. 河北师范大学化学学院, 石家庄 050016 |
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| 基金项目： | 中国科学院“百人计划”资助，科学技术部基础研究快速反应资助，河北省自然科学基金 (批准号 :5 0 3 167)资助 |
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| 摘 要： | 硅胶是目前应用最为广泛的色谱载体. 硅胶的比表面积及孔体积大, 渗透性好, 孔结构适宜于色谱分离, 但在pH＜2及pH＞8条件下不稳定, 对碱性化合物, 尤其是对生物样品产生不可逆吸附. 氧化锆化学性质非常稳定[1], 适宜碱性样品尤其是生物大分子的分离; 但是其比表面积和孔体积小[2～5], 孔结构对色谱分离不利[6], 可涂敷的固定相量较小, 渗透性差. 本文采用分子自组装方法[7～9]在微米硅球表面包覆多层纳米氧化锆制备了较为理想的色谱载体.
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| 关 键 词： | 新型色谱载体 分子自组装 ZrO2/SiO2 |
| 文章编号： | 0251-0790(2003)12-2192-03 |
| 收稿时间： | 2002-12-10 |
Preparation and Characterization of Zirconia Nanoparticle Multilayers on Micrometer-sized Silica Particle for HPLC Support |
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| DUN Hui-Juan,SONG Xiu-Qin,WEI Yu,LI Yong-Min,CHEN Li-Ren. Preparation and Characterization of Zirconia Nanoparticle Multilayers on Micrometer-sized Silica Particle for HPLC Support[J]. Chemical Research In Chinese Universities, 2003, 24(12): 2192-2194 |
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| Authors: | DUN Hui-Juan SONG Xiu-Qin WEI Yu LI Yong-Min CHEN Li-Ren |
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| Affiliation: | 1. Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China;2. College of Chemistry, Hebei Normal University, Shijiazhuang 050016, China |
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| Abstract: | The uniform zirconia nanoparticle multilayers/micrometer-sized silica particle(ZrO2/SiO2) was prepared for HPLC support material by layer-by-layer(LbL)self-assembly technique. XRD pattern shows that the crystalline of nanometer particles on the surface is pure tetragonal zirconia, with a diameter of 13.9 nm. The specific surface area, pore volume and pore size of the material are 172.53m2/g, 0.3784cm3/g, and 8.5 nm, respectively. The novel support not only has the mechanical strength and chemical stability of zirconia, but also has the good chromatographic features such as larger surface area, better permeability, less background pressure. |
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| Keywords: | Novel HPLC support Molecular self-assembly ZrO 2/SiO 2 |
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