Phosphorescent thymidine triphosphate sensor based on a donor-acceptor ensemble system using intermolecular energy transfer |
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Authors: | Kwon Tae-Hyuk Kim Hee Jin Hong Jong-In |
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Institution: | Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151-747 (Korea). |
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Abstract: | An ensemble sensor system that exhibited selective luminescence enhancement upon binding to thymidine 5'-triphosphate (TTP) in HEPES buffer over other nucleotides was developed. The ensemble system consisted of an energy acceptor (FIrpic-bis(Zn2+-dipicolylamine conjugate, FIrpic=bis(4,6-difluorophenyl)-pyridinato-N,C2+]picolinate) derivative) and an energy donor (mCP-Zn2+-cyclen, mCP=N,N'-dicarbazolyl-3,5-benzene). Among the nucleotides, the selective recognition and luminescence enhancement for TTP was achieved by the strong binding of the thymine unit to Zn2+-cyclen (cyclen=1,4,7,10-tetraazacyclododecane) and intermolecular energy transfer between the mCP and FIrpic moieties. |
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Keywords: | donor–acceptor systems intermolecular energy transfer luminescence phosphorescence sensors |
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