Mg-catalyzed enantioselective benzylic C-H bond functionalization of isoindolinones: addition to imines |
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Authors: | Suzuki Yudai Kanai Motomu Matsunaga Shigeki |
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Affiliation: | Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. |
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Abstract: | Access to chiral isoindolinones: The Mg-catalyzed enantioselective benzylic C-H bond functionalization of isoindolinones is described. A Bu(2) Mg/Schiff base catalyst (1:1) promoted the enantioselective addition of N-Boc-isoindolinones to aryl, heteroaryl, alkenyl, and alkyl imines, giving 3-substituted isoindolinones in 84-99?%?ee and 50:50-91:9?d.r. (see scheme). |
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