Synthesis, singlet oxygen photogeneration and DNA photocleavage of porphyrins with nitrogen heterocycle tails |
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Authors: | Zheng Yun-Man Wang Kai Li Tian Zhang Xiu-Lan Li Zao-Yin |
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Affiliation: | College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China. yunman@126.com |
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Abstract: | Eight novel compounds were prepared by reaction of 5-(bromo- propoxyphenyl)-10,15,20-triphenylporphyrin with oxazole thiols, 1,3,4-oxadiazole thiols and 1,3,4-thiadiazole thiols, and their structures confirmed by UV-vis, IR, 1H-NMR, MS and elemental analysis. The assessment of indirectly measured 1O(2) production rates against 5,10,15,20-tetraphenyl porphyrin (H(2)TPP) were described and the relative singlet oxygen production yields were:porphyrin 5 > porphyrins 1, 3, 4, 6-8, H(2)TPP > porphyrin 2. Porphyrin 4 and porphyrin 7 showed substantial photocleavage activities toward DNA, with over 75% cleavage observed at 40 μM. It suggested that these those porphyrins with nitrogen heterocycle tails are potential photosensitive agents. |
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