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Diastereoselective synthesis of a core fragment of ritonavir and lopinavir |
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| Authors: | Arnab RoyLekkala Amarnath Reddy Namrata DwivediJyothirmayi Naram Rodda SwapnaGolla China Malakondaiah Mylavarpu RavikumarDinesh Bhalerao Taduri Bhanu PratapPadi Pratap Reddy Apurba BhattacharyaRakeshwar Bandichhor |
| Affiliation: | API, R&D, IPDO-Innovation Plaza, Dr. Reddy’s Laboratories Ltd, Bachupalli, Qutubullapur, R. R. District, 500 072 Andhra Pradesh, India |
| Abstract: | A novel approach to the synthesis of Boc-core, a key starting material for ritonavir and lopinavir involving an unprecedented diastereoselective nitroaldol reaction on β-amino aldehyde is disclosed. |
| Keywords: | Asymmetric nitroaldol reaction Henry reaction Diastereoselective synthesis HIV protease inhibitors β-Amino aldehyde |
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