Dynamic remodelling of synapses can occur in the absence of the parent cell body |
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| Authors: | Natalia L Bettini Thomas S Moores Becki Baxter Jim Deuchars Simon H Parson |
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| Institution: | (1) University of Leeds, Institute of Membrane and Systems Biology, Faculty of Biological Sciences, Garstang Building, LS2 9JT, UK;(2) Sussex Centre for Neuroscience, School of Life Sciences, FalmerUniversity of Sussex, BN1 9QG Brighton, UK;(3) Section of Anatomy, Centre for Integrative Physiology, University of Edinburgh, Old Medical School, EH8 9AG Edinburgh, UK |
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| Abstract: | Background Retraction of nerve terminals is a characteristic feature of development, injury and insult and may herald many neurodegenerative
diseases. Although morphological events have been well characterized, we know relatively little about the nature of the underlying
cellular machinery. Evidence suggests a strong local component in determining which neuronal branches and synapses are lost,
but a greater understanding of this basic neurological process is required. Here we test the hypothesis that nerve terminals
are semi-autonomous and able to rapidly respond to local stimuli in the absence of communication with their parent cell body. |
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