| 竹红菌甲素与肌红蛋白和血红蛋白相互作用的同步荧光光谱研究 |
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| 引用本文： | 吴晓红,周家宏,顾晓天,魏少华,冯玉英,陆天虹,王雪松,张宝文.竹红菌甲素与肌红蛋白和血红蛋白相互作用的同步荧光光谱研究[J].光谱学与光谱分析,2006,26(12):2287-2290. |
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| 作者姓名： | 吴晓红 周家宏 顾晓天 魏少华 冯玉英 陆天虹 王雪松 张宝文 |
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| 作者单位： | 南京师范大学化学与环境科学学院,江苏,南京,210097;南京师范大学分析测试中心,江苏省生物医药功能材料工程研究中心,江苏,南京,210097;中国科学院理化技术研究所,北京,100101 |
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| 基金项目： | 江苏省教育厅自然科学基金
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国家自然科学基金 |
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| 摘 要： | 利用同步荧光光谱方法研究了竹红菌甲素(HA)对肌红蛋白和血红蛋白构象的影响。结果表明，HA能够使肌红蛋白和血红蛋白的构象发生改变，导致蛋白质分子中色氨酸和酪氨酸残基所处微环境由原来的疏水环境不同程度地向亲水环境转变。
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| 关 键 词： | 竹红菌甲素 肌红蛋白 血红蛋白 同步荧光光谱 |
| 文章编号： | 1000-0593（2006）12-2287-04 |
| 收稿时间： | 2005-11-18 |
| 修稿时间： | 2006-03-06 |
Study on Interaction between Hypocrellin A and Hemoglobin or Myoglobin Using Synchronous Fluorescence Spectra |
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| WU Xiao-hong,ZHOU Jia-hong,GU Xiao-tian,WEI Shao-hua,FENG Yu-ying,LU Tian-hong,WANG Xue-song,ZHANG Bao-wen.Study on Interaction between Hypocrellin A and Hemoglobin or Myoglobin Using Synchronous Fluorescence Spectra[J].Spectroscopy and Spectral Analysis,2006,26(12):2287-2290. |
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| Authors: | WU Xiao-hong ZHOU Jia-hong GU Xiao-tian WEI Shao-hua FENG Yu-ying LU Tian-hong WANG Xue-song ZHANG Bao-wen |
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| Institution: | 1. Analysis and Testing Center, Nanjing Normal University, Jiangsu Engineering Research Center of Bio-Medical Function Materials, Nanjing 210097, China2. College of Chemistry and Environment Science, Nanjing Normal University, Nanjing 210097, China3. Technical Institute of Piysics and Chemistry, Chinese Academy of Sciences, Beijing 100101, China |
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| Abstract: | The effects of hypocrellin A(HA) on the conformational changes of hemoglobin and myoglobin were studied using synchronous fluorescence spectroscopy.The results indicated that HA can change the conformation of these two proteins,leading to the change in the micro-environment of tryptophane and tyrosine residues from hydrophobic environment to hydrophilic(environment) to different extent. |
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| Keywords: | Hypocrellin A Myoglobin Hemoglobin Synchronous fluorescence spectra |
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