生物医用材料表面仿细胞膜结构改性

细胞膜因其固有的生物相容性，可以作为体内植入材料及器件表面生物相容化改性的范例。大量研究结果表明，用细胞外层膜的亲水官能团－磷酰胆碱基团修饰材料表面，可显著提高材料的生物相容性，具有广阔的应用前景。本文综述了用含磷酰胆碱基团小分子及聚合物进行仿细胞膜结构改性的各种方法及其代表性工作；讨论了不同方法得到的仿细胞膜结构表面的性能；总结了几种有影响的生物相容性机理；对仿细胞膜结构表面改性研究及应用的前景做了展望。

Surface Modification of Biomedical Materials with Cell Membrane Mimetic Structures

The cell membrane establishes an important paradigm for the surface modification of implantable devices because of its intrinsic biocompatibility. Numerous researches have suggested that the biocompatibility of materials can be improved remarkably after modified with phosphorylcholine group, which is the major head group of the phospholipid of the cells outer membrane. This kind of membrane mimetic surfaces shows practical and scientifically importance in variety of biomaterials. The methods of fabricating membrane mimetic surfaces are categorized and the resulting surface properties are discussed along with introducing the representative researches. Several important mechanisms of biocompatibiliy are also summarized. Finally, the prospects of the research on membrane mimetic surfaces are suggested.