Rhodium-catalyzed [2 + 2 + 2] cyclotrimerization in an aqueous-organic biphasic system |
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Authors: | Kinoshita Hidenori Shinokubo Hiroshi Oshima Koichiro |
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Institution: | Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 606-8501, Japan. |
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Abstract: | Macrocyclization via rhodium-catalyzed intramolecular 2 + 2 + 2] annulation of triynes has been explored in an aqueous-organic biphasic system. The biphasic system controls the concentration of hydrophobic substrates in the aqueous reaction phase and offers diluted reaction conditions without the use of a slow addition technique. The system also achieves selective cross-annulation between hydrophobic diynes and hydrophilic alkynes. |
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