Methylphosphonothionates of N-(β-hydroxypropyl)anabasine — Synthesis,structure, and sensitivity of cholinesterases to them |
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Authors: | D. N. Dalimov M. B. Gafurov Z. Tilyabaev F. G. Kamaev A. A. Abdugakhabov |
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Abstract: | The synthesis has been effected of alkyl anabasinoprop-2-yl and alkyl piperidinoprop-2-yl methylphosphonothionates. It has been shown by1H,13C and31P NMR spectroscopies that the anabasine derivatives exist in solution as four diastereomeric forms. The kinetics of the interaction of the compounds synthesized with two types of cholinesterases has been studied.A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Fax 627071. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 70–74, January–February, 1994. |
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