Self-organization of a chiral D-EAK16 designer peptide into a 3D nanofiber scaffold |
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Authors: | Luo Zhongli Zhao Xiaojun Zhang Shuguang |
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Institution: | West China Hospital, Laboratory for Nanobiomedical Technology, Sichuan University, Chengdu, Sichuan 610065, China. |
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Abstract: | Self-assembling peptide nanofiber scaffolds are an excellent material for applications such as tissue repair, tissue regeneration, instant stopping of bleeding, and slow drug release. We report a new self-assembling peptide D-EAK16 consisting purely of D-amino acids. D-EAK16 and L-EAK16 display mirror-image CD spectra at 20 degrees C. Like L-EAK16, D-EAK16 self-assembles into nanofibers, thus demonstrating that chiral self-assembling peptide nanofiber scaffolds can be made from both L- and D-amino acids. We also show that D-peptide nanofibers are resistant to natural proteases and may thus be useful in biotechnology, nanobiotechnology, tissue repair and tissue regeneration as well as other medical applications. |
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Keywords: | atomic force microscopy (AFM) chirality circular dichroism D‐peptides self‐assembly SEM |
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