Interaction of Cupidin/Homer2 with two actin cytoskeletal regulators, Cdc42 small GTPase and Drebrin, in dendritic spines |
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| Authors: | Yoko Shiraishi-Yamaguchi Yumi Sato Rieko Sakai Akihiro Mizutani Thomas Kn?pfel Nozomu Mori Katsuhiko Mikoshiba and Teiichi Furuichi |
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| Institution: | (1) Laboratory for Molecular Neurogenesis, RIKEN Brain Science Institute, 351-0198 Wako, Saitama, Japan;(2) Department of Anatomy and Neurobiology, Nagasaki University School of Medicine, 852-8523 Nagasaki, Nagasaki, Japan;(3) Laboratory for Neuronal Circuit Dynamics, RIKEN Brain Science Institute, 351-0198 Wako, Saitama, Japan;(4) Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, 351-0198 Wako, Saitama, Japan;(5) JST,CREST, 102-0075 Chiyoda-ku, Tokyo, Japan |
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| Abstract: | Background Homer is a postsynaptic scaffold protein that links various synaptic signaling proteins, including the type I metabotropic
glutamate receptor subunits 1α and 5, the inositol 1,4,5-trisphosphate receptor, Shank and Cdc42 small GTPase. Overexpression
of Homer induces changes in dendritic spine morphology in cultured hippocampal neurons. However, the molecular basis underpinning
Homer-mediated spine morphogenesis remains unclear. In this study, we aimed to elucidate the structural and functional properties
of the interaction between Cupidin/Homer2 and two actin-cytoskeletal regulators, Cdc42 small GTPase and Drebrin. |
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