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Formation of the imidazolinone ring under mild conditions in the presence of sodium hydride
Authors:Vasiliev Aleksey N  Lopez Antonio F  Fernandez Julio D  Mocchi Anibal J
Institution:Center for Chemical Research and Technologies, Cordoba Faculty, National Technological University, C.C. 17, Suc. 16, Cordoba 5016, Argentina. vasiliev@scdt.frc.utn.edu.ar
Abstract:Substituted imidazolinones containing heterocyclic carboxylic acids as substituents and possessing herbicidal properties were synthesized by cyclization of 2-amino-2,3-dimethylbutyramide with heterocyclic ethyl dicarboxylates under mild conditions. The use of NaH as base leads to a significant increase in the reaction rate and allows the preparation of the target compounds in high yields.
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