A novel series of 2,5-disubstituted 1,3,4-thiadiazoles as potential anticonvulsant agent |
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Authors: | Harish Rajak Chinmay K.Beheraa Rajesh S.Pawarb Pradeep K.Singourb Murli Dhar Kharyac a SLT Institute of Pharmaceutical Sciences Guru Ghasidas University Bilaspur- India b VNS Institute of Pharmacy Neelbud Bhopal- India c |
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Affiliation: | a SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur-495 009, (C. G.), India;b VNS Institute of Pharmacy, Neelbud, Bhopal-462 044, (M. P.), India;c Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar-470 003, (M. P.), India |
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Abstract: | In pursuit for better antiepileptic drug and the importance of semicarbazones and 2,5-disubstituted 1,3,4-thiadiazoles as anticonvulsant pharmacophore, a series of novel N-({5-[(6-methyl-1-benzofuran-3-yl)methyl]-1,3,4-thiadiazol-2-yl}carbamothioyl)-2/3/4-substitutedbenzamide were designed, synthesized and evaluated for their anticonvulsant activity. The findings of the present studies confirmed that the pharmacophore model with four binding sites is crucial for anticonvulsant activity. Structure-activity relationships among synthesized compounds were also established. |
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Keywords: | 1,3,4-Thiadiazoles Semicarbazones Anticonvulsant activity |
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