Doubly hydrophilic multiarm hyperbranched polymers with acylhydrazone linkages as acid-sensitive drug carriers |
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| Authors: | Wang Qiang Zhu Lijuan Li Guolin Tu Chunlai Pang Yan Jin Chengyu Zhu Bangshang Zhu Xinyuan Liu Yingqun |
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| Institution: | Department of Children's Oral, the Stomatology, College of Haerbin Medical University, Nangang District, Haerbin, China. |
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| Abstract: | A novel type of drug carrier capable of controlled drug release is proposed. It consists of an acid-sensitive doubly hydrophilic multiarm hyperbranched copolymer with a hyperbranched polyamidoamine core and many linear poly(ethylene glycol) arms. Using pH-sensitive acylhydrazone linkages, the polymer forms unimolecular micelles that can encapsulate hydrophobic drugs. Due to their amphiphilicity, the drug-loaded unimolecular micelles can self-assemble into multimolecular micelles that show acid-triggered intracellular delivery of the hydrophobic drugs. |
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| Keywords: | acylhydrazone bond drug delivery systems hyperbranched polymers pH‐sensitive self‐assembly |
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