PEGylated anti-MUC1 aptamer-doxorubicin complex for targeted drug delivery to MCF7 breast cancer cells |
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Authors: | Tan Lihan Neoh Koon Gee Kang En-Tang Choe Woo Seok Su Xiaodi |
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Affiliation: | Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge, 119260, Singapore. |
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Abstract: | Targeted drug delivery is especially important in cancer treatment as many anti-cancer drugs are non-specific and highly toxic to both cancer and normal cells. The targeted drug delivery of DOX to the MUC1-expressing breast cancer cell line (MCF7) was obtained using APT as a carrier. Modification of the APT-DOX complex by PEG increases the survivability of the macrophage control (RAW 264.7) by about six-fold as compared to free DOX treatment without significantly affecting the cytotoxicity toward the target cell line. Thus, PEG-APT-DOX is potentially a new therapeutic agent for targeted drug delivery to MUC1-expressing cell lines. |
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Keywords: | aptamers biological applications of polymers breast cancer doxorubicin drug delivery systems |
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