Asymmetric synthesis of 3-hydroxy-pyrrolidines via tin-lithium exchange and cyclization |
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| Authors: | Christoph Guido Stratmann Christian Coldham Iain Hoppe Dieter |
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| Institution: | Organisch-Chemisches Institut, Westf?lische Wilhelms-Universit?t Münster, Corrensstrasse 40, D-48149 Münster, Germany. |
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| Abstract: | We report a method for the synthesis of chiral pyrrolidines using tin-lithium exchange and cyclization reactions. The precursors are formed readily from simple starting materials and undergo tin-lithium exchange by treatment with n-butyllithium. Subsequent intramolecular carbolithiation is stereoselective to give highly enantiomerically enriched pyrrolidines in excellent yields. |
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