| IL-1β regulates the mouse Fas ligand expression in corneal endothelial cells |
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| 作者姓名： | ZHANG Jie Yang Ke TAN DeYong ZENG JunYing Alan FINE |
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| 作者单位： | [1]Department of Biochemistry and Molecular Biology, School of Life Science, Yunnan University, Kunming 650091, China [2]Pulmonary Center and the Department of Biochemistry, Boston University School of Medicine, MA 02118, USA |
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| 基金项目： | Supported by the National Natural Science Foundation of China （Grant No. 30260027） |
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| 摘 要： | Constitutively expressed Fas ligand (FasL) in several distinct epithelial cell types appears to protect tissues by inducing apoptosis of Fas immune cells during inflammatory reactions. To study the rela-tionship of FasL and inflammation process in cornea,we examined the effects of inflammatory cytokine IL-1β on the FasL production,expression and cytotoxic function in corneal endothelial cells. In this paper,we demonstrate that IL-1β inhibits the FasL production and expression in corneal endothelial cells. The promoter activities of FasL in these cells are reduced by IL-1β in a dose-dependent manner. Finally,we also find that IL-1β block the cytotoxic effects of FasL derived from corneal endothelial cells to the Fas target cells. These data support the view that FasL derived from corneal endothelial cells modulate inflammation within cornea.
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| 关 键 词： | FasL promoter cornea IL-1β Mouse |
| 收稿时间： | 18 December 2006 |
| 修稿时间： | 2006-11-18 |
IL-1β regulates the mouse Fas ligand expression in corneal endothelial cells |
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| ZHANG Jie Yang Ke TAN DeYong ZENG JunYing Alan FINE.IL-1β regulates the mouse Fas ligand expression in corneal endothelial cells[J].Chinese Science Bulletin,2007,52(16):2210-2215. |
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| Authors: | Zhang Jie Yang Ke Tan DeYong Zeng JunYing Alan Fine |
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| Institution: | (1) Department of Biochemistry and Molecular Biology, School of Life Science, Yunnan University, Kunming, 650091, China;(2) Pulmonary Center and the Department of Biochemistry, Boston University School of Medicine, MA 02118, USA |
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| Abstract: | Constitutively expressed Fas ligand (FasL) in several distinct epithelial cell types appears to protect tissues by inducing
apoptosis of Fas+ immune cells during inflammatory reactions. To study the relationship of FasL and inflammation process in cornea, we examined
the effects of inflammatory cytokine IL-1β on the FasL production, expression and cytotoxic function in corneal endothelial
cells. In this paper, we demonstrate that IL-1β inhibits the FasL production and expression in corneal endothelial cells.
The promoter activities of FasL in these cells are reduced by IL-1β in a dose-dependent manner. Finally, we also find that
IL-1β block the cytotoxic effects of FasL derived from corneal endothelial cells to the Fas+ target cells. These data support the view that FasL derived from corneal endothelial cells modulate inflammation within cornea.
Supported by the National Natural Science Foundation of China (Grant No. 30260027) |
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| Keywords: | FasL promoter cornea IL-1β Mouse |
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