A palladium-catalyzed C–H functionalization route to ketones via the oxidative coupling of arenes with carbon monoxide |
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| Authors: | Taleah M Levesque R Garrison Kinney Bruce A Arndtsen |
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| Institution: | Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal QC H3A 0B8 Canada, |
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| Abstract: | We describe the development of a new palladium-catalyzed method to generate ketones via the oxidative coupling of two arenes and CO. This transformation is catalyzed by simple palladium salts, and is postulated to proceed via the conversion of arenes into high energy aroyl triflate electrophiles. Exploiting the latter can also allow the synthesis of unsymmetrical ketones from two different arenes.A palladium catalyzed route to prepare aryl ketones from their two fundamental building blocks, two arenes and carbon monoxide, is described. |
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