| 咪唑[2，1-b]噻唑多胺缀合物的合成与表征 |
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| 引用本文： | 扈晓艳,徐括喜,杨丽. 咪唑[2，1-b]噻唑多胺缀合物的合成与表征[J]. 化学研究, 2009, 20(2): 69-71 |
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| 作者姓名： | 扈晓艳 徐括喜 杨丽 |
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| 作者单位： | 河南大学,化学化工学院,河南,开封,475004 |
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| 基金项目： | 河南省科技厅基础与前沿技术研究项目，河南大学校内基金 |
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| 摘 要： | 以2-氨基噻唑和溴乙酰基吡啶为原料合成了二个咪唑[2，1-b]噻唑的甲酰基化合物3，4，然后与N1-氨基丁基-N1，N4-二叔丁氧羰基-1，4-丁二胺经缩合后用NaBH4还原，产物提纯后脱保护得目标产物7、8，并通过IR，^1H NMR，^13C NMR，ESI-MS对目标化合物的结构进行了表征．
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| 关 键 词： | 咪唑[2 1-b]噻唑 多胺 三胺衍生物 多胺缀合物 |
Synthesis and Characterization of Imidazo[2,1-b]thiazoles Polyamine Conjugates |
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| HU Xiao-yan,XU Kuo-xi,YANG Li. Synthesis and Characterization of Imidazo[2,1-b]thiazoles Polyamine Conjugates[J]. Chemical Research, 2009, 20(2): 69-71 |
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| Authors: | HU Xiao-yan XU Kuo-xi YANG Li |
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| Affiliation: | ( College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, Henan, China) |
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| Abstract: | Imidazo [2,1-b] thiazole aldehydes(3,4) were prepared by the reactions of 2-aminothiazole and 2-bromoacetophenone as starting materials.Compound 3 or 4 was treated with N1-(4aminobutyl)-N1,N4-di-tert-butoxycarbonylbutane-1,4-diamine,then condensed with 9-anthraldehyde,and the crude product was reduced with NaBH4.After purification,the reduced product was deprotected to obtain the final compounds.The composition and structures of the final compounds were confirmed by IR,1H NMR,13C NMR and ESI-MS. |
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| Keywords: | imidazo [2,1-b] thiazole polyamine triamine derivative polyamine comjugate |
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