Further cytotoxic sesquiterpene lactones from Elephantopus mollis KUNTH |
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Authors: | Tabopda Turibio Kuiate Ngoupayo Joseph Liu Jiawei Shaiq Ali Muhammad Khan Shamsun Nahar Ngadjui Bonaventure Tchaleu Luu Bang |
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Affiliation: | Département de Chimie Organique, Université de Yaoundé I, BP 812 Yaoundé, Cameroun. ttabopda@yahoo.fr |
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Abstract: | Three new sesquiterpene lactones, (4betaH)-5alpha-hydroxy-8alpha-(2-methylbut-2-enoyloxy)-2-oxo-1(10),11(13)-guaiadien-12,6alpha-olide (1), (4betaH)-8alpha-(2-methylbut-2-enoyloxy)-2-oxo-1(5),10(14),11(13)-guaiatrien-12,6alpha-olide (2) and 2,5-epoxy-2beta-hydroxy-4alpha-methoxy-8alpha-(2-methylbut-2-enoyloxy)-4(15),10(14),11(13)-germacratrien-12,6alpha-olide (3), have been isolated from roots and stems of Elephantopus mollis together with two known sesquiterpene lactones (4, 5). The identification of the isolates was accomplished by spectroscopic methods. Compounds (1-5) exhibited significant cytotoxic activities against mouse neuroblastoma B104 cells. |
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