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Synthesis and binding behaviors of monomethyl cucurbit[6]uril
Authors:Mostafa M. Ahmed  Kazutaka KogaMakoto Fukudome  Hideaki SasakiDe-Qi Yuan
Affiliation:a Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Minatojima 1-1-3, Chuo-ku, Kobe 650-8586, Japan
b Department of Molecular Medicinal Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Bunkyo-machi 1-14, Nagasaki 852-8521, Japan
c Nihon Pharmaceutical University, Kita-adachi, Saitama 362-0806, Japan
Abstract:By reacting 3a-methylglycoluril and glycoluril with paraformaldehyde, monomethyl cucurbit[6]uril was synthesized in 14% yield. The new host molecule forms stable inclusion complexes with diamine and hexylaminocarbazole derivatives.
Keywords:Cucurbituril   Functionalization   Synthesis   Molecular recognition
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