Sesquiterpenes and alkaloids from Lindera chunii and their inhibitory activities against HIV-1 integrase |
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Authors: | Zhang Chao-feng Nakamura Norio Tewtrakul Supinya Hattori Masao Sun Qi-shi Wang Zheng-tao Fujiwara Tamio |
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Institution: | Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan. |
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Abstract: | Three new eudesmane type sesquiterpenoid lindenanolides E (1), F (2) and G (3), and two new aporphine alkaloid lindechunines A (18) and B (20) were isolated from roots of Lindera chunii MERR., together with seven known sesquiterpenes including a new naturally-occurring lindenanolide H (4) and eight known aporphine alkaloids. The structures of these compounds were determined by spectroscopic means. Of the isolated compounds, hernandonine (14), laurolistine (16), 7-oxohernangerine (17) and lindechunine A (18) showed significant anti-human immunodeficiency virus type 1 (HIV-1) integrase activity with IC(50) values of 16.3, 7.7, 18.2 and 21.1 microM, respectively. The major alkaloids presented in the roots of L. chunii were quantitatively analyzed by an HPLC method. |
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