pH-sensitive vesicles based on a biocompatible zwitterionic diblock copolymer |
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| Authors: | Du Jianzhong Tang Yiqing Lewis Andrew L Armes Steven P |
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| Institution: | Department of Chemistry, The University of Sheffield, Brook Hill, Sheffield S3 7HF, United Kingdom. |
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| Abstract: | Highly biocompatible pH-sensitive diblock copolymer vesicles were prepared from the self-assembly of a biocompatible zwitterionic copolymer, poly2-(methacryloyloxy)ethyl phosphorylcholine-block-2-(diisopropylamino)ethyl methacrylate], PMPC-b-PDPA. Vesicle formation occurred spontaneously by adjusting the solution pH from pH 2 to above 6, with the hydrophobic PDPA chains forming the vesicle walls. Transmission electron microscopy (TEM), dynamic laser light scattering (DLS), and UV-visible absorption spectrophotometry were used to characterize these vesicles. Gold nanoparticle-decorated vesicles were also obtained by treating the vesicles with HAuCl4, followed by NaBH4. |
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