Nitro derivatives of 2,1,3-benzothiadiazole 1-oxides: synthesis,structural study,and NO release |
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| Authors: | L. S. Konstantinova E. A. Knyazeva Yu. V. Gatilov S. G. Zlotin O. A. Rakitin |
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| Affiliation: | 1.N. D. Zelinsky Institute of Organic Chemistry,Russian Academy of Sciences,Moscow,Russian Federation;2.N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch,Russian Academy of Sciences,Novosibirsk,Russian Federation |
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| Abstract: | A convenient one-pot synthesis of nitro derivatives of 2,1,3-benzothiadiazole 1-oxides by the reaction of o-nitroanilines with sulfur monochloride was developed. The structural features of 4-nitrobenzothiadiazole and its N-oxide were considered. High in vitro release of nitric oxide (69%) was found for a 6-nitro-2,1,3-benzothiadiazole sample by the Griess assay, which indicated good prospects for this class of compounds. |
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