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Photoluminescent decoration of iron oxide magnetic nanoparticles for dual-imaging applications |
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| Authors: | Antonio Palumbo Piccionello Luca Menichetti Paolo Armanetti Alessandra Flori Ilaria Monaco Mirko Maturi Andrea Pace Erica Locatelli |
| Institution: | 1.Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche. STEBICEF,Università degli Studi di Palermo,Palermo,Italy;2.CNR Institute of Clinical Physiology,Pisa,Italy;3.CNR/Fondazione Toscana G. Monasterio,Pisa,Italy;4.Department of Industrial Chemistry “Toso Montanari”,Bologna,Italy |
| Abstract: | A selective functionalization of dopamine amino group with the photoluminescent 7-nitroben-zofurazan was achieved through a one-pot protection-functionalization-deprotection sequence. The resulting fluorescent catecholic ligand was used as a capping agent for iron oxide nanoparticles thus obtaining photoluminescent magnetic nanoparticles (PL-MNPs). The PL-MNPs were then embedded into PLGA-b-PEG polymeric nanocarriers which quenched the emission of the capping agent. Full recovery of fluorescence was observed after disassembling the polymeric layer of the nanoparticle, thus supporting the use of PL-MNPs as a multifunctional system for targeted drug delivery. |
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