The inhibition of the mammalian DNA methyltransferase 3a (Dnmt3a) by dietary black tea and coffee polyphenols |
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| Authors: | Arumugam Rajavelu Zumrad Tulyasheva Rakesh Jaiswal Albert Jeltsch Nikolai Kuhnert |
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| Affiliation: | (1) Chemistry, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany;(2) Biochemistry, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany;(3) MoLife program, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany |
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| Abstract: | Background Black tea is, second only to water, the most consumed beverage globally. Previously, the inhibition of DNA methyltransferase 1 was shown by dietary polyphenols and epi-gallocatechin gallate (EGCG), the main polyphenolic constituent of green tea, and 5-caffeoyl quinic acid, the main phenolic constituent of the green coffee bean. |
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