| First total synthesis of 10α-hydroxy-4-muurolen-3-one and its C10-isomer |
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| 作者姓名： | Fu Qiang Bi Li Jing Fang Chen Xi Zhang Yu Lin Li |
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| 作者单位： | State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000, China |
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| 基金项目： | Acknowledgment We are grateful for the financial supports from the National Natural Science Foundation of China （No. 20272021） |
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| 摘 要： | An efficient synthetic route to muurolane type sesquiterpenes starting from （R）-carvone, employing allylic diazene rearrangement and the ring closing methesis （RCM） reaction as key steps, is described. The first asymmetric total synthesis of （-）-10α- hydroxy-4-muurolen-3-one 11 and （-）-10β-hydroxy-4-muurolen-3-one C was accomplished. Through the total synthesis, the absolute configurations of the natural products A, B and C were established.
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| 关 键 词： | 异构体 合成方法 烯丙基 羟基 二氮烯 |
| 收稿时间： | 20 March 2008 |
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