Sub-Second Accumulation and Stripping for Pico-Level Monitoring of Amikacin Sulphate by Fast Fourier Transform Cyclic Voltammetry at a Gold Microelectrode in Flow-Injection Systems |
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| Authors: | Parviz Norouzi Gholam-Reza Nabi Bidhendi Mohammad Reza Ganjali Ali Sepehri Maryam Ghorbani |
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| Institution: | (1) Institute of Analytical Science, Northwest University, 710069 Xi an, China |
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| Abstract: | A novel chemiluminogenic reagent, refered to as spiro form fluorescein hydrazide, was synthesized, and its application to chemiluminescence (CL) determination of Co2+ is described. The method is based on the catalytic effect of Co2+ on the autoxidation of sulfite in basic solution to generate a series of powerful oxidative intermediates, which then oxidize colorless, nonfluoresent fluorescein hydrazide to generate strong CL emission. The CL signal is linearly related to the concentration of Co2+ in the range of 0.1–200 nM with a detection limit of 0.04nM. The optimal conditions for the detection of Co2+ were evaluated, and the possible CL mechanism is discussed. The proposed method has been applied to the determination of Co2+ in pharmaceutical preparations and in soil samples. |
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| Keywords: | : Fluorescein hydrazide cobalt(II) sulfite chemiluminescence flow injection |
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