Biodegradable Photothermal and pH Responsive Calcium Carbonate@Phospholipid@Acetalated Dextran Hybrid Platform for Advancing Biomedical Applications |
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| Authors: | Hongbo Zhang Dongfei Liu Weixia Zhang Liyuan Zhang Hélder A Santos Mingtan Hai |
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| Institution: | 1. Beijing Key Laboratory of Function Materials for Molecule & Structure Construction, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, P. R. China;2. Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA;3. Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland |
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| Abstract: | A biodegradable multifunctional carrier for combination therapy with high efficiency and low side effect is essential for effective cancer treatment and for advancing biomedical applications. Therapeutics combination could reduce multidrug resistance and minimize doses through synergism. This study develops biodegradable gold nanorods@calcium carbonate particles coated with pH‐responsive acetalated dextran and phospholipid as an advanced platform for the incorporation of versatile molecular targeted therapeutics, including hydrophilic and hydrophobic drugs, as well as the model enzyme, green fluorescent protein, or antibody. The developed calcium carbonate based hybrid particles show good biocompatibility, stability with photothermal, and pH responsiveness, which protect the payloads from premature release, and maintain the enzyme activity. The therapeutics co‐loaded CaCO3 based hybrid particles efficiently induce cancer cell death and reduce the multidrug resistance and HER2 expression with synergism. The photothermal effects promote ultrafast therapeutics release and induce significant cytotoxicity. Importantly, Anti‐HER2 antibody or HER2 targeted therapeutic is more effective in reducing HER2 expression when combined with drug or drugs via synergism. Overall, the cheap and simply manufactured biodegradable hybrid platform has great potential for advancing biomedical applications, including targeted photothermal combination therapy by co‐delivery of different types of therapeutics, including molecular targeted drugs, antibodies, and enzymes. |
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| Keywords: | biomedical applications enzyme and antibody co‐delivery multidrug resistance inhibition photothermal and pH responsiveness targeted cancer therapy |
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