蛋氨酸负荷后大鼠主动脉血管内皮细胞早期形态扫描电镜观察

为探讨蛋氨酸负荷对大鼠主动脉血管内皮细胞早期形态的影响,将雄性Wistar大鼠随机分为正常饮食对照组(对照组)和蛋氨酸负荷组(蛋氨酸组),对照组喂饲普通饲料,蛋氨酸负荷组大鼠喂饲含3%蛋氨酸的饲料,共8周,用扫描电镜观察了主动脉弓血管内皮细胞形态.结果表明,蛋氨酸负荷后大鼠主动脉弓内皮细胞呈典型虫蛀样损害,伴有附壁血栓...

Scanning Electron Microscope of Aorta Endothelium in Rats Fed with Methionine Loading

To observe the effects of endothelial secretive function in rats fed with high methionine diets,male wistar rats are randomly divided into the normal diet group(CR)and high methionine diet group(MR).After 8 weeks,plasma homocysteine level,bodyweight and equal daily diet were measured,the endothelium ultrastructure changes in aorta wall were observed with scanning electron microscope.The results syowed that the rat’s endothelial cells of blood vessel of group CR were relatively unanimous in size,arrange closely along the axis of ordinates of blood vessel.The ones of group MR were damaged obviously,the cell surface shrinks.Endothelium to be damaging by worms kinds of harming typical,with enclose wall thrombus form and with the fat quality depositing.Plasma homocysteine level of MR increased twofold as compared with that of CR(P<0.05).It concluded rats fed with himethionine diet could be led to hyperhomocysteinemia,and a serious early change of endothelium.