Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acid |
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| Authors: | Khedri Zahra Muthana Musleh M Li Yanhong Muthana Saddam M Yu Hai Cao Hongzhi Chen Xi |
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| Affiliation: | Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA. |
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| Abstract: | A library of α2-3- and α2-6-linked sialyl galactosides containing C9-modified sialic acids was synthesized from C6-modified mannose derivatives using an efficient one-pot three-enzyme system. These sialosides were used in a high-throughput sialidase substrate specificity assay to elucidate the importance of C9-OH in sialidase recognition. |
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