Ieodoglucomides A and B from a marine-derived bacterium Bacillus licheniformis |
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Authors: | Tareq Fakir Shahidullah Kim Ji Hye Lee Min Ah Lee Hyi-Seung Lee Yeon-Ju Lee Jong Seok Shin Hee Jae |
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Affiliation: | Department of Marine Biotechnology, University of Science and Technology, 217 Gajungro, Yuseong-gu, Daejeon, Republic of Korea. |
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Abstract: | Ieodoglucomides A (1) and B (2), unique glycolipopeptides consisting of an amino acid, a new fatty acid, a succinic acid, and a sugar, were isolated from a Marine-derived bacterium Bacillus licheniformis. The absolute stereochemistry of 1 and 2 was determined by deploying coupling constants, Marfey's and Mosher's methods, and literature reviews. Compounds 1 and 2 displayed moderate in vitro antimicrobial activity. Furthermore, ieodoglucomide B (2) exhibited cytotoxic activity against lung cancer and stomach cancer cell lines with GI(50) values of 25.18 and 17.78 μg/mL, respectively. |
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