Palladium-catalyzed regio- and stereoselective hydrosilylation of electron-deficient alkynes |
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| Authors: | Sumida Yuto Kato Tomoe Yoshida Suguru Hosoya Takamitsu |
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| Affiliation: | Laboratory of Chemical Biology, Graduate School of Biomedical Science, Institute of Biomaterials and Bioengineerings, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan. |
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| Abstract: | Highly regio- and stereoselective hydrosilylation applicable to a broad range of electron-deficient alkynes has been established using palladium catalysis. The synthetic utility of the method has been demonstrated by further transformations of α-silylalkenes, particularly Hiyama coupling and stereoinverting iododesilylation followed by Suzuki-Miyaura coupling, which enables stereodivergent syntheses of α-arylenoates. |
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