Synthetic polymer nanoparticles conjugated with FimH(A) from E. coli pili to emulate the bacterial mode of epithelial internalization |
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| Authors: | Lin Lily Yun Tiemann Kristin M Li Yali Pinkner Jerome S Walker Jennifer N Hultgren Scott J Hunstad David A Wooley Karen L |
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| Institution: | Department of Chemistry and Chemical Engineering, Texas A&M University, P.O. Box 30012, College Station, Texas 77842, USA. |
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| Abstract: | Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimH(A) through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro. |
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