| 利用石英微天平技术实时监控纤维蛋白原与改性后氧化钛薄膜的界面反应 |
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| 引用本文： | 赵安莎,王昭,朱晓华,Manfred F. Maitz,黄楠. 利用石英微天平技术实时监控纤维蛋白原与改性后氧化钛薄膜的界面反应[J]. 化学物理学报, 2014, 27(3): 355-360 |
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| 作者姓名： | 赵安莎 王昭 朱晓华 Manfred F. Maitz 黄楠 |
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| 作者单位： | 西南交通大学材料先进技术教育部重点实验室，材料科学与工程学院，成都 610031;西南交通大学材料先进技术教育部重点实验室，材料科学与工程学院，成都 610031;西南交通大学材料先进技术教育部重点实验室，材料科学与工程学院，成都 610031;德累斯顿莱布尼茨高分子研究所，德国德累斯顿马克斯伯格曼生物材料中心，德累斯顿;西南交通大学材料先进技术教育部重点实验室，材料科学与工程学院，成都 610031 |
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| 摘 要： | 利用石英微天平技术实时研究了纤维蛋白原与改性后氧化钛薄膜的界面分子作用. 纤维蛋白原αC和γ链特异性抗体被用来进一步表征和检测纤维蛋白原在界面的吸附形态及构象变化. 结果显示纤维蛋白原在亲水性表面更倾向于通过αC结构域直立着吸附，这种吸附方式减少了位于纤维蛋白原γ链上血小板结合位点的暴露从而减少了血小板的粘附及激活.
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| 关 键 词： | 石英微天平技术，纤维蛋白原吸附，构象变化，血小板 |
| 收稿时间： | 2013-12-18 |
Real-Time Characterization of Fibrinogen Interaction with Modified Titanium Dioxide Film by Quartz Crystal Microbalance with Dissipation |
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| An-sha Zhao,Zhao Wang,Xiao-hua Zhu,Manfred F. Maitz and Nan Huang. Real-Time Characterization of Fibrinogen Interaction with Modified Titanium Dioxide Film by Quartz Crystal Microbalance with Dissipation[J]. Chinese Journal of Chemical Physics, 2014, 27(3): 355-360 |
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| Authors: | An-sha Zhao Zhao Wang Xiao-hua Zhu Manfred F. Maitz Nan Huang |
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| Affiliation: | Key Laboratory of Advanced Materials Technology of Ministry of Education, Department of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China;Key Laboratory of Advanced Materials Technology of Ministry of Education, Department of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China;Key Laboratory of Advanced Materials Technology of Ministry of Education, Department of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China;Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials Dresden, Dresden, Germany;Key Laboratory of Advanced Materials Technology of Ministry of Education, Department of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China |
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| Abstract: | |
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| Keywords: | Quartz crystal microbalance with dissipation Fibrinogen adsorption Confor-mation change Blood platelet |
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