| 两亲性类树枝状聚合物的合成与药物控释 |
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| 引用本文： | 王帅鹏,宋晓婉,冯晓双,陈鹏,钱家盛,夏茹,苗继斌. 两亲性类树枝状聚合物的合成与药物控释[J]. 化学物理学报, 2014, 27(5): 587-592 |
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| 作者姓名： | 王帅鹏 宋晓婉 冯晓双 陈鹏 钱家盛 夏茹 苗继斌 |
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| 作者单位： | 安徽大学化学化工学院，安徽省高分子绿色材料重点实验室，合肥 230601;安徽大学化学化工学院，安徽省高分子绿色材料重点实验室，合肥 230601;阿卜杜拉国王科技大学物理科学工程部，图瓦 23955-6900;安徽大学化学化工学院，安徽省高分子绿色材料重点实验室，合肥 230601;安徽大学化学化工学院，安徽省高分子绿色材料重点实验室，合肥 230601;安徽大学化学化工学院，安徽省高分子绿色材料重点实验室，合肥 230601;安徽大学化学化工学院，安徽省高分子绿色材料重点实验室，合肥 230601 |
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| 摘 要： | 结合阴离子开环聚合方法合成了内壳为聚(乙氧基乙基缩水甘油醚)，外层为聚环氧乙烷的两亲性类树枝状嵌段共聚物PEEGE-G2-b-PEO(OH)12. 使用核磁共振氢谱以及凝胶渗透色谱等表征了中间产物和目标产物. 选择阿霉素作为实验药物，研究了该聚合物的载药和控释行为. 聚合物的载药率和包覆效率分别为13.07%和45.75%，体外释放试验表现为持续性的释放，并受到释放介质pH影响.
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| 关 键 词： | 阴离子开环聚合，活性聚合，类树枝状聚合物，两亲性嵌段聚合物，药物缓释 |
| 收稿时间： | 2014-04-14 |
Synthesis of an Amphiphilic Dendrimer-Like Block Copolymer and Its Application on Drug Delivery |
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| Shuai-peng Wang,Xiao-wan Song,Xiao-shuang Feng,Peng Chen,Jia-sheng Qian,Ru Xia and Ji-bin Miao. Synthesis of an Amphiphilic Dendrimer-Like Block Copolymer and Its Application on Drug Delivery[J]. Chinese Journal of Chemical Physics, 2014, 27(5): 587-592 |
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| Authors: | Shuai-peng Wang Xiao-wan Song Xiao-shuang Feng Peng Chen Jia-sheng Qian Ru Xia Ji-bin Miao |
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| Affiliation: | School of Chemistry and Chemical Engineering, Anhui University, Key Laboratory of Environment-friendly Polymer Materials of Anhui Province, Hefei 230601, China;School of Chemistry and Chemical Engineering, Anhui University, Key Laboratory of Environment-friendly Polymer Materials of Anhui Province, Hefei 230601, China;Division of Physical Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Saudi Arabia;School of Chemistry and Chemical Engineering, Anhui University, Key Laboratory of Environment-friendly Polymer Materials of Anhui Province, Hefei 230601, China;School of Chemistry and Chemical Engineering, Anhui University, Key Laboratory of Environment-friendly Polymer Materials of Anhui Province, Hefei 230601, China;School of Chemistry and Chemical Engineering, Anhui University, Key Laboratory of Environment-friendly Polymer Materials of Anhui Province, Hefei 230601, China;School of Chemistry and Chemical Engineering, Anhui University, Key Laboratory of Environment-friendly Polymer Materials of Anhui Province, Hefei 230601, China |
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| Abstract: | Dendrimer-like amphiphilic copolymer is a kind of three-dimensional spherical structure polymer. An amphiphilic dendrimer-like diblock copolymer, PEEGE-G2-b-PEO(OH)12, constituted of a hydrophobic poly(ethoxyethyl glycidol ether) inner core and a hydrophilic poly(ethylene oxide) outer layer, has been successfully synthesized by the living anionic ring-opening polymerization method. The intermediates and targeted products were charac-terized with 1H NMR spectroscopy and gel permeation chromatography. The application on drug delivery of dendrimer-like diblock copolymer PEEGE-G2-b-PEO(OH)12 using DOX as a model drug was also studied. The drug loading content and encapsulation e ciency were found at 13.07% and 45.75%, respectively. In vitro release experiment results indicated that the drug-loaded micelles exhibited a sustained release behavior under acidic media. |
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| Keywords: | Anionic ring opening polymerization Living polymerization Dendrimer-like copolymer Amphiphilic diblock copolymer Drug delivery |
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